BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF TETRACYCLINES ON SPONTANEOUS OSTEOARTHRITIS IN GUINEA PIGS
Matrix metalloproteinases (MMPs) are mediators in connective tissue destruction in a variety of pathologic processes.Recently discovered chemically modified tetracyclines have been found to be effective inhibitors of MMP mediated connective tissue degradation in both rheumatoid arthritis (RA) and osteoarthritis (OA).The ventilationstejp Hartley gui